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Eric J. Munson Ph.D.

Professor

Departments: Pharmaceutical Chemistry
Office: 236A Simons
Email: Munson@ku.edu
Phone: (785) 864-3319
Fax: (785) 864-5736

Educational Background:

B. A., 1987, Augustana College, South Dakota
Ph. D., 1993, Texas A&M University
Postdoctoral Fellow, 1993-94, University of California, Berkeley

Research Group:

Dewey Barich: Research Associate
Bob Berendt : Graduate Student
Eric Gorman: Graduate Student
Benjamin Nelson : Graduate Student
Sarah Pyszczynski: Graduate Student
Loren Schieber: Graduate Student
Diana Sperger: Graduate Student

Research Interests:

The application of analytical techniques, especially solid-state NMR spectrometry, to the characterization of pharmaceutical solids; investigation of the structure and reactivity of pharmaceutical agents in polymer matrices; correlation of solid-state NMR chemical shifts with molecular structure; investigation of the transformations between crystalline and amorphous forms of pharmaceutical solids; effect of processing upon drug structure and stability; investigation of peptide and protein stability in formulations; effects of freeze drying upon drug stability.

Professor Munson?fs research interests lie in the area of using solid-state NMR spectroscopy, powder X-ray diffraction, and other techniques to characterize solid pharmaceuticals. Differences in the crystalline state of a drug may significantly change its physical and thermodynamic properties. For many drugs, multiple crystalline polymorphs exist whose crystal structures are not known. Solid-state 13C magic-angle spinning (MAS) NMR spectroscopy is a powerful technique for studying polymorphic systems. It can be used to determine the degree of crystallinity, to identify the number of crystallographically inequivalent sites in the unit cell, to study the dynamics of molecules via relaxation measurements, and to understand the molecular structure based on the chemical shift of the individual resonances.

Specific research areas that are being pursued in his group include the investigation of the structure and reactivity of pharmaceutical agents in polymer matrices; correlation of solid-state NMR chemical shifts with molecular structure; investigation of the transformations between crystalline and amorphous forms of pharmaceutical solids; effect of processing upon drug structure and stability; investigation of peptide and protein stability in formulations; and the effects of freeze drying upon drug stability.

Current Research Projects:

Publications:

Nelson, B. N.; Schieber, L. J.; Barich, D. H.; Lubach, J. W.; Offerdahl, T. J.; Lewis, D. H.; Heinrich, J. P.; Munson, E. J. “Multiple-Sample Probe for Solid-State NMR Studies of Pharmaceuticals”, Solid State NMR, in press.

Sheth, A. R.; Lubach, J. W.; Munson, E. J.; Muller, F. X.; Grant, D. J. W. “Mechanochromism of Piroxicam Accomplished by Intermolecular Proton Transfer Probes by Spectroscopic Methods and Solid-Phase Changes”, J. Am. Chem. Soc., 2005, 127, 6641-6651.

Dong, Z.; Brennessel, W. W.; Padden, B. P.; Schroeder, S. A.; Prakash, I.; Young, Jr., V. A.; Munson, E. J.; Grant, D. J.W. “Crystal Structure and Physical Characterization of N-(3,3-Dimethylbutyl)-L-?-Aspartyl-L-Phenylalanine, The Hydrolysis Product of Neotame”, J. Chem. Crystal., 2005, 35, 233-241.

Li, B.; O’Meara, M. H.; Lubach, J. W.; Schowen, R. L.; Topp, E. M.; Munson, E. J.; Borchardt, R. T. “Effects of Sucrose and Mannitol on Asparagine Deamidation Rates of Model Peptides in Solution and in the Solid State”, J. Pharm. Sci., 2005, 94, 1723-1735.

Barrón, L. B.; Waterman, K. C.; Offerdahl, T. J.; Munson, E. J.; Schöneich, C. “Reactions of aliphatic thiyl radicals in the solid state: photoisomerization of trans-4,5-dihydroxy-1,2-ditihia-cyclohexane and oxidation of dithiothreitol”, J. Phys. Chem., 2005, 109, 9241-9248.

Offerdahl, T. K.; Salsbury, J. S.; Dong, Z.; Grant, D. J. W.; Schroeder, S. A.; Prakash, I.; Munson, E. J. “Quantitation of Crystalline and Amorphous Forms of Anhydrous Neotame Using 13C CPMAS NMR Spectroscopy”, J. Pharm. Sci., 2005, 94, 2591-2605.

Lubach, J. W.; Padden, B. E.; Winslow, S. L.; Salsbury, J. S.; Masters, D. B.; Topp, E. M.; Munson, E. J. “Solid-State NMR Studies of Pharmaceutical Solids in Polymer Matrices”, Anal. Bioanal. Chem., 2004, 378, 1504-1510.

Barich, D. H.; Zell, M. T.; Powell, D. R.; Munson, E. J. “2,4-Dimethoxy acid and 2,5-dimethoxybenzoic acid”, Acta Crystallographica, Section C: Crystal Structure Communications, 2004, C60, o261-o262.

D’Souza, A. J.; Schowen, R. L.; Borchardt, R. T.; Salsbury, J. S.; Munson, E. J.; Topp, E. M. “Reaction of a Peptide with Polyvinylpyrrolidone in the Solid State”, J. Pharm. Sci., 2003, 92, 585-593.

Dong, Z.; Young, Jr., V. A.; Munson, E. J.; Schroeder, S. A.; Prakash, I.; Grant, D. J.W. “Crystal Structures of the Benzene and Ethanol Solvates of Neotame”, J. Chem. Crystal, 2003, 33, 787-793.